Alexander Zverev has lost all three of his previous meetings with Rafael Nadal on clay
British number one Dan Evans missed out on the Madrid Open quarter-finals after losing to German fifth seed Alexander Zverev in the last 16.
Zverev, the 2018 champion, won 6-3 7-6 (6-3) and faces top seed Rafael Nadal in the last eight.
Evans, 30, paid the price for a one-sided first set, before being edged out of the second set tie-break.
Nadal comfortably reached his 15th Madrid quarter-final with a 6-3 6-3 win over world number 76 Alexei Popyrin.
Facing the 21-year-old Australian for the first time, Nadal won four of his six break points as he moved closer to a record-extending sixth title in the Spanish capital.
Austria's Dominic Thiem, Madrid finalist in 2017 and 2018, also reached the quarter-finals after beating Australia's Alex de Minaur 7-6 (9-7) 6-4.
US Open champion Thiem will face USA's John Isner in the last eight after the world number 39 beat Russia's sixth seed Andrey Rublev 7-6 (7-4) 3-6, 7-6 (7-4).
World number three Daniil Medvedev continued to struggle on clay with a 6-4, 6-7 (2-7), 6-1 defeat by Chilean 16th seed Cristian Garin.
There was also an upset for fourth seed Stefanos Tsitsipas as the Greek was beaten 7-6 (7-4) 6-4 by Norweigan world number 22 Casper Ruud.
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